JACK SZOSTAK - MASSACHUSETTS GENERAL HOSPITAL

Fruit St., Boston, MA  02114
Phone:  617-726-5981     Fax:  617-726-6893     Email:  szostak@molbio.mgh.harvard.edu

Title and Role

Co-Investigator - Responsible for studies on directed evolution of peptides and proteins relevant to the early evolution of peptide and protein function.

Related Experience Summary

Co-developer of directed evolution approach to RNA evolution. Co-inventor of mRNA-display approach to in vitro directed protein evolution. Direct laboratory of over 20 post-doctoral fellows, graduate students and technicians.

Employment History

1988-Professor, Department of Genetics, Harvard Medical School
1988-Molecular Biologist, Department of Molecular Biology, MGH
1997-Investigator, Howard Hughes Medical Institute
2000-Alex Rich Distinguished Investigator, Department of Molecular Biology, MGH

Education

1977, Ph.D., Cornell University, Ithaca, New York, (Biochemistry)

Professional Societies

National Academy of Sciences
American Academy of Arts and Sciences
Fellow of New York Academy of Sciences
Member American Chemical Society, AAAS, ISSOL.

Awards and Honors

1994, National Academy of Sciences Award in Molecular Biology
1997, Hans Sigrist Prize, University of Bern, Switzerland
2000, Genetics Society of America Medal

Selected Relevant Publications

Szostak JW, Bartel DP, Luisi PL. Synthesizing life.  Nature, 2001; 409:387-390.

Wilson DS, Keefe AD, Szostak JW.  The use of mRNA display to select high-affinity protein-binding peptides. Proc. Natl. Acad. Sci., 2001; 98:3750-3755.

Keefe AD, Szostak JW. Functional proteins from a random sequence library. Nature, 2001; 410:715-718.

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